Drosophila models of human neurodegenerative disease
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چکیده
منابع مشابه
Drosophila as an In Vivo Model for Human Neurodegenerative Disease.
With the increase in the ageing population, neurodegenerative disease is devastating to families and poses a huge burden on society. The brain and spinal cord are extraordinarily complex: they consist of a highly organized network of neuronal and support cells that communicate in a highly specialized manner. One approach to tackling problems of such complexity is to address the scientific quest...
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As populations benefit from increasing lifespans, neurodegenerative diseases have emerged as a critical health concern. How can the fruit fly, Drosophila melanogaster, contribute to curing human diseases of the nervous system? A growing number of neurodegenerative diseases, as well as other human diseases, are being modeled in Drosophila and used as a platform to identify and validate cellular ...
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syndromes are characterized and increasing attention Prominent filamentous tau inclusions are increasingly is focused on the relationship of different FTDP-17 genorecognized as the hallmark neuropathology of a growing types to the heterogeneous phenotypic manifestations family of neurodegenerative diseases collectively known of these hereditary neurodegenerative tauopathies (Hong as tauopathies...
متن کاملGuide to Understanding Drosophila Models of Neurodegenerative Diseases
Primer I n the decade since human genes associated with neurodegenerative disease were first used in flies to create pathological phenotypes [1–5], a minor industry has sprung up using flies as a model to study the mechanisms underlying central nervous system malfunction in humans. Why study neurodegeneration in flies? Their small size, rapid generation time, and low costs for maintenance as co...
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Drosophila is one of the oldest and most powerful genetic models and has led to novel insights into a variety of biological processes. Recently, Drosophila has emerged as a model system to study human diseases, including several important neurodegenerative diseases. Because of the genomic similarity between Drosophila and humans, Drosophila neurodegenerative disease models exhibit a variety of ...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2000
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400757